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中国循证儿科杂志

中国循证儿科杂志 ›› 2019, Vol. 14 ›› Issue (5): 337-341.DOI: 10.3969/j.issn.1673-5501.2019.05.004

• 论著 • 上一篇    下一篇

TGF-β3基因多态性与亚洲人群非综合征型唇腭裂易感性的系统评价和Meta分析

陈燕1, 芮海英2, 马恩惠2, 徐涛2, 李旺阳2, 张益恒2   

  1. 1 兰州大学第一医院口腔科 兰州,730030;
    2 兰州大学第一临床医学院 兰州,730030
  • 收稿日期:2019-06-02 出版日期:2019-10-25
  • 通讯作者: 陈燕,E-mail: cheny15@lzu.edu.cn
  • 基金资助:
    2017年兰州大学第一医院院内基金:ldyyyn2017-07

Association between TGF-β3 polymorphisms and the susceptibility to non-syndromic cleft lip and cleft palate in Asian population: A systematic review and Meta-analysis

CHEN Yan 1, RUI Hai-ying 2, MA En-hui, XU Tao 2, LI Wang-yang 2, ZHANG Yi-heng 2   

  1. 1 Department of Stomatology, Lanzhou university first hospital, Lanzhou, 730030;
    2 First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
  • Received:2019-06-02 Online:2019-10-25
  • Contact: CHEN Yan, E-mail: cheny15@lzu.edu.cn

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摘要： 目的 用Meta分析的方法分析TGF-β3基因多态性与亚洲人群非综合征型唇腭裂 (NSCL/P)易感性的相关性。方法 计算机检索 PubMed、Cochrane Library、Embase、中文科技期刊全文数据库、中国期刊全文数据库、中国生物医学文献数据库和万方数据库,检索日期自建库至2019年1月31日公开发表的文献。2位研究者独立按照本文纳入和排除标准筛选文献、提取资料。采用Stata12.0软件进行 Meta分析,漏斗图观察发表偏倚。结果 9篇病例对照研究进入Meta分析。TGF-β3基因在等位基因模型(G vs A: OR=1.23, 95%CI:1.04～1.47)、相加模型(GG vs AA: OR=1.72, 95%CI:1.17～2.55)、共显性模型(GG vs GA: OR=1.50, 95%CI:1.15～1.98)和显性模型 (GG vs GA+AA: OR=1.50, 95%CI:1.16～1.94) 下与NSCL/P易感性有关;在隐性模型(AA vs GA+ GG: OR=0.97, 95%CI:0.72～1.30)二者无相关性。不同对照组人群来源亚组分析结果显示,对照组来源医院的人群,各种基因模型下差异均无统计学意义。对照来源社区人群,TGF-β3基因位点多态性在A vs G、GA vs GG和GA+AA vs GG下与NSCL/P易感性有关,AA vs GG和AA vs GG+GA无相关性。结论 TGF-β3基因多态性增加了亚洲人群NSCL/P的发病风险。

关键词: Meta分析, TGF-β3, 非综合征型唇腭裂, 基因多态性, 系统评价

Abstract: Objective To investigate the association between TGF-β3 polymorphisms and the susceptibility to non-syndromic cleft 1∶P with or without cleft palate (NSCL/P) in Asian population using Meta-analysis.Methods Electionic detabeses including PubMed, Cochrane Library, Embase, Chinese Science and Technology Academic Journal, Chinese Journal Full-text Database, Chinese Biomedical Literature Database and Wanfang database were searched for relevant literature from inception of databases to Januatr 2019. Two researchers selected the literature and extracted the data independently according to the inclusion and exclusion criteria. A Meta-analysis was performed using STATA12.0 software and publication bias test were performed by funnel Plots.Results A total of nine case-control studies were included in the present Meta-analysis, including 806 cases and 781 healthy control. Meta-analysis showed that there was significant association between TGF-β3 polymorphism and susceptibility to NSCL/P under allele model (G vs A: OR=1.23, 95%CI: 1.04-1.47), additive model (GG vs AA: OR=1.72, 95%CI: 1.17-2.55), Co-dominant model (GG vs GA: OR=1.50, 95%CI: 1.15-1.98) and dominant model (GG vs GA+AA: OR=1.50, 95%CI: 1.16-1.94). However, there was no significant association between them under recessive model (AA vs GA+GG: OR=0.97, 95%CI: 0.72-1.30).Conclusion TGF-β3 polymorphism is associated with an increased risk of NSCL/P in Asian population.

Key words: Meta-analysis, NSCL/P, Polymorphism, Systematic review, TGF-β3