欢迎访问《中国循证儿科杂志》官方网站，今天是
English Version
中国循证儿科杂志

中国循证儿科杂志 ›› 2020, Vol. 15 ›› Issue (1): 45-49.

• 论著 • 上一篇    下一篇

中国多中心新生儿重症监护室胎龄小于34周早产儿 出院前视网膜病变发生率的横断面调查

朱艳萍1,5,蒋思远2,5,王晓康1,李明霞1,杨晨皓3,曹云2,梁翼飞4,中国新生儿重症监护室协作性质量改进研究协作组
  

  1. 1 新疆医科大学第一附属医院新生儿科乌鲁木齐，830054；复旦大学附属儿科医院：2 新生儿科；3 眼科上海，201102；4 新疆医科大学儿科学院乌鲁木齐，830054；5 共同第一作者
  • 收稿日期:2020-02-24 出版日期:2020-02-25 发布日期:2020-03-16
  • 通讯作者: 曹云
  • 基金资助:
     

Incidence of retinopathy of prematurity among infants less than 34 weeks' gestation before discharge in 25 NICUs in China: A cross-sectional survey

 ZHU Yan-ping1，5, JIANG Si-yuan2，5, WANG Xiao-kang1, LI Ming-xia1, YANG Chen-hao3, CAO Yun2, LIANG Yi-fei4,Reduction of Infection in Neonatal Intensive Care Unit Using the Evidence-based Practice for Improving Quality (REIN-EPIQ) Study Group   

  1.  1 Department of Neonatology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; 2 Department of Neonatology, 3 Department of Ophthalmology, Children's Hospital of Fudan University, Shanghai 201102, China; 4 School of Pediatrics, Xinjiang Medical University, Urumqi 830054, China;5 Co-first author
  • Received:2020-02-24 Online:2020-02-25 Published:2020-03-16
  • Contact: Cao Yun
  • Supported by:
     

PDF

552

摘要： 目的:调查中国NICU胎龄<34周早产儿视网膜病变（ROP）发生率。方法:数据来源于“基于证据的质量改进方法降低我国新生儿重症监护室院内感染发生率的整群随机对照试验”所建立的早产儿临床数据库，收集25家三级NICU 2015年5月1日至2018年4月30日住院期间接受积极治疗、转出NICU或死亡前至少完成1次ROP筛查的胎龄<34周早产儿的临床资料，分析不同胎龄及出生体重早产儿的ROP发生率、分期及治疗方式，并比较各单位间的差异。结果:14 015例<34周的早产儿在出院前或死亡前至少进行了1次ROP筛查，筛查阳性2 304例（16.4%)，其中ROP1期1 092例（7.8%），ROP2期1 004例（7.2%），ROP 3~5期208例（1.5%）。胎龄<28周早产儿ROP发生率为56.5% （578/1 023），3~5期ROP发生率为9.6% （98/1 023）。出生体重<1 000 g和1 000~1 499 g早产儿ROP发生率分别为54.2% （465/858）和22.1%（1 411/6 381），3~5期ROP发生率分别为9.6% （82/858）和1.5% （95/6 381）。2 304例ROP早产儿在出院前188例（8.2%）接受治疗，其中眼内药物注射117例。各单位间ROP发生率存在显著差异。结论:胎龄<34周的早产儿的ROP发生率为16.4%， 8.2%的ROP患儿接受治疗，其中62%采用玻璃体内注药，不同单位间ROP发生率差异显著。

 

Abstract: Objective:To investigate the incidence of retinopathy of prematurity (ROP) in the premature infants less than 34 weeks' gestation in 25 neonatal intensive care units (NICU) in China. Methods:The data were from the clinical database of preterm infants established by a cluster randomized control study of "REduction of Infection in Neonatal intensive care units using the Evidencebased Practice for Improving Quality (REINEPIQ)" . All preterm infants with less than 34 weeks' gestation who received at least one ROP screening during hospitalization in 25 tertiary Chinese NICUs from May 2015 to April 2018 were enrolled. Results:A total of 14, 015 preterm infants <34 weeks' gestation received ROP screening during hospitalization during the study period. Overall 2, 304 infants (16.4%) were diagnosed with ROP. Incidence of stage 1, stage 2 and stage 3 or above were 7.8%, 7.2% and 1.5%, respectively. Among infants with gestational age <28 weeks, the incidence of ROP and stage 3 or above ROP were 56.5% and 9.6%, respectively. Among infants with birth weight <1, 000 g, the incidence of ROP and stage 3 or above ROP were 54.2% and 9.6%, respectively. Among infants with birth weight from 1, 000 g to 1, 499 g, the incidence of ROP and stage 3 or above were 22.1% and 1.5%, respectively. Among all infants with ROP, 8.2% (188) received treatment with 62% (117) receiving intraocular medicine injection. Significant variations of ROP incidence existed among the included NICUs. Conclusion:The incidence of ROP among infants <34 weeks' gestation was 16.4% in 25 tertiary Chinese NICUs with relatively high proportion of treatment and significant variations among different NICUs.

中图分类号: