Correlation between serum adipokines and metabolic characteristics in obese children and adolescents

doi:10.3969/j.issn.1673-5501.2019.05.011

Chinese Journal of Evidence -Based Pediatric ›› 2019, Vol. 14 ›› Issue (5): 374-379.DOI: 10.3969/j.issn.1673-5501.2019.05.011

• Original Papers • Previous Articles Next Articles

Correlation between serum adipokines and metabolic characteristics in obese children and adolescents

DU Su-su¹, PENG Lu-ting¹, WU Su², JIANG Zhi-ying¹, LING Ru¹, YU Ting¹, LIU Qian-qi², LI Xiao-nan¹

1 Department of Children Health Care, Children's Hospital of Nanjing Medial university, Nanjing 210008, China;
2 Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China

Received:2019-08-28 Online:2019-10-25
Contact: LI Xiao-nan, E-mail: xiaonan6189@163.com

Abstract

Abstract: Objective To investigate the relationship between four adipokines (leptin, adiponectin, Nrg4 and ZAG) and obesity and related metabolic disorders.Methods Obese children aged from 5 to 14 years were recruited from Children's Health Department of Children's Hospital of Nanjing Medical University. We measured height, weight, WC, fat mass percentage (FM%) and blood pressure, then calculated waist height ratio (WHtR) and BMISDS. Indicators of glucose and lipid metabolism were measured. Serum adipokines levels were measured by enzyme-linked immunosorbent assays (ELISA).According to blood pressure, glucose and lipid metabolism indicators, obese children were divided into metabolically unhealthy obesity (MUO) and metabolically healthy obesity (MHO). Then association between serum adipokines, obesity and metabolic status was analyzed.Results A total of 192 obese children were recruited in the study (138 boys and 54 girls, 10.59±1.93 years), with average BMISDS of 2.86 (2.38, 3.26). Among the obese children, 164 cases (85.4%) were MUO and 28 cases (14.6%) were MHO. After adjusting for age, MUO children had lower adiponectin and Nrg4 levels compared to MHO children (all P<0.05). Serum leptin and ZAG levels were no significant difference between the two groups. Correlation analysis indicated that serum leptin levels in MUO group were positively correlated with BMISDS, FM% and WHtR (P<0.05). Serum adiponectin levels were negatively correlated with age, ALT, AST and HOMA-IR (P<0.05). Serum Nrg4 levels were negatively correlated with BMISDS, WHtR, ALT and AST(P<0.05). Serum ZAG levels were negatively correlated with FM% (P<0.05). Logistic regression analysis showed that serum adiponectin and Nrg4 were protective factors for metabolism in obese children. ROC analysis showed that the diagnostic cut-off points of serum adiponectin and Nrg4 evaluating metabolic abnormalities in obese children were 5.56 μg·mL^-1 and 5.5 ng·mL^-1, respectively.Conclusions erum leptin and ZAG levels in obese children and adolescents with metabolic disorders are closely related to fat mass, while adiponectin and Nrg4 levels are associated with the degree of metabolic disorders. These adipokines are important for identifying and interfering with the occurrence and development of metabolic disorders in obese children and adolescents.

Key words: Adipokines, Children and adolescents, Metabolism, Obesity

DU Su-su, PENG Lu-ting, WU Su, JIANG Zhi-ying, LING Ru, YU Ting, LIU Qian-qi, LI Xiao-nan. Correlation between serum adipokines and metabolic characteristics in obese children and adolescents[J]. Chinese Journal of Evidence -Based Pediatric, 2019, 14(5): 374-379.

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Correlation between serum adipokines and metabolic characteristics in obese children and adolescents

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