Chinese Journal of Evidence -Based Pediatric ›› 2015, Vol. 10 ›› Issue (6): 443-448.

• Original Papers • Previous Articles     Next Articles

The association between renin-angiotensin gene polymorphisms and risk of childhood hypertension: a systematic review and meta-analysis

YE Bing-bing, SU Dan-yan, LIU Dong-li, QIN Su-yuan, LAO Jin-quan, PANG Yu-sheng   

  1. Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Autonomous Region, China
  • Received:2015-10-08 Revised:2015-12-24 Online:2015-12-05 Published:2015-12-04
  • Contact: PANG Yu-sheng

Abstract:

Objective To explore the association between the genetic markers angiotensin converting enzyme (ACE) (I/D), angiotensinogen (ANG) (M235T) and angiotensin Ⅱ receptor-1 [STBX]AT1R[STBZ] (A1166C) and risk of hypertension in pediatric subjects. Methods EMBASE, PubMed, Hartford User Group Exchange (HUGE), CNKI, VIP, Wanfang data and CBM database were searched for the case-control studies on the association of three gene polymorphisms with hypertension in pediatric patients from the establishment to November 27th 2015. Data extraction, quality assessment and pooled analysis were conducted. Meta-analysis on the association of three gene polymorphisms with hypertension between hypertension group and control group under recessiveness, dominance, co-dominance, addition and allele gene models were performed. Statistical analysis was performed by Stata 12.0 software. Results A total of 824 patients and 1 731 controls from 7 case-control studies with moderate bias risk were included. An association between hypertension and ACE (I/D) D variant was identified in 6 included studies in the meta-analysis under recessive model (OR=1.405, 95%CI =1.073-1.840, P=0.013). Neither ANG (M235T) polymorphism in 3 enrolled studies nor [STBX]AT1R[STBZ] (A1166C) polymorphism in 2 enrolled studies was associated with hypertension in pediatric population under recessiveness, dominance, co-dominance, addition or allele gene models. Subgroup analysis revealed that ACE (I/D) D variant was associated with an increased risk of hypertension in obese pediatric population under recessive model(OR=1.564 , 95%CI:1.054-2.321, P=0.026), additive model (OR=2.017, 95%CI:1.137-3.576, P=0.016) and allele model (OR=1.406, 95%CI: 1.076-1.838, P=0.013). There were no significant differences in the frequencies distribution of ACE (I/D) between two groups in general population by considering ethnicity and classification of hypertension. Conclusion No significant association was found between ANG M235T, [STBX]AT1R[STBZ] A1166C polymorphisms and hypertension in pediatric population. The ACE (I/D) polymorphism might be associated with susceptibility to hypertension in the obese pediatric population.