Chinese Journal of Evidence -Based Pediatric ›› 2015, Vol. 10 ›› Issue (6): 434-437.

• Original Papers • Previous Articles     Next Articles

Cross-sectional study on newborn congenital cytomegalovirus infection in a tertiary special hospital and a community hospital in Shanghai

YE Li-jing1, DONG Niu-niu2, YE Ying-zi1, XU Jin2, YU Hui1   

  1. 1 Department of Infectious Diseases, 2 Laboratory of Infectious Diseases, Children's Hospital of Fudan University; Shanghai 201102, China
  • Received:2015-06-19 Revised:2015-12-24 Online:2015-12-05 Published:2015-12-04
  • Contact: YU Hui, XU Jin

Abstract:

Objective To estimate the prevalence of congenital cytomegalovirus (CMV) in Shanghai by analyzing the situation of congenital cytomegalovirus infection in newborns. Methods Relevant data of the live births were collected, who were systematically screened for neonatal diseases by using dry blood spot (DBS) samples derived from heel picking in the Affiliated Obstetrics and Gynecology Hospital of Fudan University, referred to as the Maternity Hospital of Fudan University, and in Pujiang Town Community Health Center Hospital in Minhang District, Shanghai, called Pujiang Hospital for short. CMV DNA loading in the rest of DBS after the neonatal diseases screening, was detected by fluorescence quantitative PCR. Risk factors of congenital CMV infection were analyzed according to the neonatal medical records and telephone follow-up. The risk factors included the following definitions: ① Neonatal sex; ② Gestational age (<37 weeks, ~42 weeks, ≥42 weeks) ; ③ Birth weight (<2 500 g, ~3 999 g, ≥4 000 g) ; ④ Maternal age( 25-29 years old, first births >30 years old or ≥35 years old);⑤ Native place(Shanghai, Non Shanghai);⑥ Mothers' educational status (junior school degree or below, high school, university degree or above); ⑥ Current family population(≤3 family members, 4 family members,>5 family members). Results ① Among 1 780 DBS of newborn screening collected from neonatal heel peripheral blood within 3 days from September 2011 to March 2013, 942 of which were from the Pujiang Hospital and the rest were from the Maternity Hospital of Fudan University. The congenital CMV infection rate of the two hospitals was 0.9%(17/1 780). 1.6% (15/942) for the former and 0.2% (2/838) for the latter, with significant difference between the two groups (P=0.003 4). ②1 530 neonatal and mothers' medical records and telephone follow-ups were collected. There was a significant difference in mothers' education levels between the CMV positive and negative groups (P=0.008 5), but the difference of other risk factors had no statistical significance. Conclusion The congenital CMV infection rate was 0.9% in Shanghai. There was no obvious correlation between congenital CMV infection rates and the neonatal sex, gestational age, birth weight, mothers' native place and family size. There was statistically significance in mothers' educational status between the negative and positive groups.