Abstract:

Objective ASQ-C is a newly introduced and standardized questionnaire for children's development in China. The validity of ASQ-C was not fully tested .In this study, the Gesell developmental scale was used as a diagnostic scale to test the validity of the ASQ-C in high risk children. Methods The 130 samples were selected in the outpatient of children development, who were evaluated by both ASQ-C and Gesell development scale. Cutoff points for all ASQ-3 age-versions were calculated in two ways and the samples were divided into 2 groups according to the age. The sensitivity, specificity, positive and negative predictive values were calculated. The subscales of ASQ-C were analyzed according to the corresponding scales of Gesell development scale. Results In generally, the coincidence rate was 0.73， sensitivity and specificity were 72.5% (95%CI:63% to 82%)and 74.3%(95%CI:61% to 88%),the PPV and NPV were 86.8%(95%CI:79% to 94%)and 53.7%(95%CI:40% to 67%).Using 1 s as the cutoff, the sensitivity and specificity were 92.5% and 32.4%, the PPV and NPV were 77.5%(95%CI:70% to 85%)and 63.2%(95%CI:41% to 85%).Sensitivity and specificity values were higher for the older age-cohort than for the younger age-cohort. The sensitivity and specificity of the subscale were 46.6% to 85% and 64.3% to 93.7%. Conclusion The ASQ-C was a developmental screening scale, its validity was within acceptable range, but failed to reach the ideal screening scale level. For less than 18 months of high-risk children, using 1s as the cutoff may significantly improve the sensitivity and reduce missed diagnosis.