Abstract:

Objective To investigate the risk factors and prediction of unresponsiveness to intravenous immunoglobulin (IVIG) retreatment in patients with Kawasaki disease(KD).Methods From Jan 2010 to Jan 2015, the clinical and laboratory features of 81KD patients in Children's Hospital of Chongqing Medical University retreated with IVIG were retrospectively analyzed.Results Eighty one KD patients were enrolled. The incidence of IVIG retreatment - responsive group was 75.31% (61/81), while IVIG retreatment - unresponsive group was 24.69% (20/81). There were no statistical differences in the gender, age, the clinical features before or after initial IVIG treatment, the interval of IVIG for two times between two groups. Before initial IVIG, there were no statistical differences in the incidences of coronary artery lesions, laboratory features including WBC, PLT, Hb, N, CRP, ALT, AST and electrolyte between two groups. After initial IVIG treatment, there were no statistical differences in the amplitude of variation in WBC, PLT,N%, Hb and CRP between two groups.Conclusion The clinical manifestations and laboratory features before initial IVIG treatment could not predict the unresponsiveness to IVIG retreatment. Similarly, the clinical manifestations and the peripheral blood cell counts examination after initial IVIG treatment had no prediction for the unresponsiveness to IVIG retreatment.