Chinese Journal of Evidence -Based Pediatric ›› 2016, Vol. 11 ›› Issue (2): 157-160.
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YANG Mei-xiong1, TANG Qing1, LV Zi-li2, WANG Lin-lin1, OU Jia-lian1, SHAN Qing-wen1
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【Abstract】 Objective:The purpose of this paper is to investigate,summarize the clinical characteristics,and provide evidence for the diagnosis and treatment of infants with autoimmune hepatitis (AIH).Methods:Based on 2 cases of AIH in our hospital we analyzed patient's symptoms,physical signs,results of their auxiliary examination,the corresponding theurapeutic schemes results,and the literature data.Results:Thrombocytopenia and abnormal liver function were the original symptoms.Hepatosplenomegaly were the main clinical manifestations in those 2 patients.Patient's liver function test,immunoglobulin,serum antibodies,liver biopsy results,and good response to corticosteroid alone or in combination with azathiprine (AZA) all supported the diagnosis of AIH.Conclusions:The clinical symptoms of AIH disease may not specific and AIH is considered rare in the infant population.Clinicians should always consider AIH in children presenting with chronic or acute liver disease.Liver biopsy is required as soon as possible to establish the diagnosis,it can provide evidence for the treatment,drug withdrawal,and prognosis.Once the diagnosis is clear, treatment should be instituted as soon as possible to avoid progression of the disease and it consist of corticosteroids alone or in combination with azathioprine (AZA).
YANG Mei-xiong, TANG Qing, LV Zi-li, WANG Lin-lin, OU Jia-lian, SHAN Qing-wen. Analyzed 2 infant patients with autoimmune hepatitis whose original symptom was thrombocytopenia[J]. Chinese Journal of Evidence -Based Pediatric, 2016, 11(2): 157-160.
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