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Chinese Journal of Evidence -Based Pediatric ›› 2017, Vol. 12 ›› Issue (4): 273-277.

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Post-newborn period: a new concept of age period in early life after birth

The Cooperative Group for the Multi-center Study of Post-newborn Period, a New Concept of Age Period in Early Life after Birth, CHEN Long1,16, LI Jie2,16, WANG Yan3,16, HOU Jian-ming4,16, YAN Jun5,16, WANG Jun-xia6,16, HE Zhi-hui7,16, TAN Shu-jiang8,16, PU Xiang-yang9,16, REN Xiao-ling10,16,CHEN Jing 11,16, JIANG Shou-fu12,16, YI Bin 13,16,ZHU Qiong 14,16, MA Juan1, WANG Li1,TANG Shi-fang1, ZHAO Jin-ning1, LI Wan-wei 1, LI Xia 1, WU Fang 1, GONG Fang3,  ZENG Yi-wen3, MO Yun-bo4, TAN Qiu4,HU Ling 5, YE Hai-yan5, GUO Lin-mei6, LI Yan-li7, CHEN Yuan-chun8, JIANG Xiao-hua8, DENG Sheng-yong9, WEI Gui-yu9, WANG Ying10, PAN Hong10, WANG Cheng-xiu11, CHEN Cong11, XU Rui-feng13, SHI Yuan1,15   

  1. 1 Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China; 2 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400014, China; 3 Yongchuan Hospital of Chongqing Medical University, Yongchuan 402160, China;4 Children's Hospital, Three Gorges Central Hospital, Wanzhou 404100, China; 5 Department of Pediatrics, The First People's Hospital of Jiulongpo, Chongqing 400050, China; 6 PLA General Hospital of Lanzhou, Lanzhou 530050, China; 7 The Ninth People's Hospital of Chongqing, Chongqing 400700, China; 8 Central Hospital of Fuling, Fuling 408000, China; 9 Central Hospital of Qianjiang, Qianjiang 409000, China; 10 Central Hospital of Qijiang, Qijiang 401420, China; 11 The Fifth People's Hospital of Chongqing, Chongqing 400060, China; 12 People's Hospital of Tongliang, Tongliang 402560, China; 13 Maternal and Child Central Hospital of Gansu Province, Lanzhou 730050, China; 14 Maternal and Child Central Hospital of Hechuan, Hechuan 401520, China; 15 Children's Hospital of Chongqing Medical University, Chongqing 400014, China; 16 Co-first author
  • Received:2017-06-07 Revised:2017-07-12 Online:2017-08-25 Published:2017-08-25
  • Contact: SHI Yuan

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Abstract:

目的：通过调查新生儿期（0~28 d）、新生儿后期（~100 d）和改良婴儿期（~1岁）病死率和死因谱，为新生儿后期新概念提供初步的临床证据支持。方法：在中国西部新生儿协作网采用整群随机抽样方法抽取14家医院，采用回顾性横断面调查方法，采集14家医院2004年1月至2013年12月住院婴儿新生儿期、新生儿后期和改良婴儿期的第一出院的或病死的诊断。结果：在10年期间，共有155 463例住院婴儿进入本文分析，死亡959例，病死率为6.16‰；新生儿期、新生儿后期和改良婴儿期病死率分别为10.1‰、6.9‰和2.6‰，新生儿后期与新生儿期和改良婴儿期差异均有统计学意义。新生儿期632例死亡病例中前6个死亡原因依次为新生儿窒息、新生儿呼吸窘迫综合征（NRDS）、先天心脏病（CHD）、早产相关疾病（PAD）、婴儿猝死综合征(SIDS)和肺炎，新生儿后期148例死亡病例中前6个死亡原因依次为肺炎、CHD、PAD、腹泻、SIDS和维生素K1缺乏，改良婴儿期188例死亡病例中前6个死亡原因依次为肺炎、CHD、意外伤害、SIDS、PAD和腹泻。新生儿期、新生儿后期和改良婴儿期同时出现的死因性疾病PAD、肺炎、SIDS和CHD，病死率最高是新生儿后期(P＜0.001)。结论：在未校正胎龄和喂养方式混杂因素的情况下，新生儿后期疾病病死率及其病因具有特殊性，可能具有特别的临床意义。