Molecular characteristics of antibiotic resistance and virulence in community acquired methicillin-resistant Staphylococcus aureus from neonates with skin and soft tissue infections

Chinese Journal of Evidence -Based Pediatric ›› 2019, Vol. 14 ›› Issue (6): 438-442.

• Original Papers • Previous Articles Next Articles

Molecular characteristics of antibiotic resistance and virulence in community acquired methicillin-resistant Staphylococcus aureus from neonates with skin and soft tissue infections

GENG Wen-jing¹, LI Wen-ting², SHI Wei³, HEI Ming-yan¹

1 Neonatal Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China; 2 Respiratory Department, Qilu Children’s Hospital of Shandong University, Jinan 250000, China; 3 MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China

Received:2019-12-09 Revised:2019-12-11 Online:2019-12-25 Published:2019-12-25
Contact: HEI Ming-yan
Supported by:

Abstract

Abstract: ObjectiveTo study the characteristics of the molecular, drug resistance and virulence in community acquired methicillin-resistant staphylococcus aureus from neonates with skin and soft tissue infections. MethodsCA-MRSA isolates were prospectively collected from Beijing Children's Hospital. All the isolates were characterized by staphylococcal chromosomal cassette (SCCmec) type, staphylococcal protein A (spa) type and multilocus sequence type (MLST). Superantigen toxin gene, sasX gene, antimicrobial susceptibility were also detected. ResultsCellulitis of umbilicus was the most common case, and the most common CA-MRSA clones were ST59-SCCmecIVa-t437. The sasX gene was not detected. Four isolates were oxacillin-susceptible. ConclusionCellulitis of umbilicus was the most common case in neonates with skin and soft tissue infections, and ST59-SCCmecIVa-t437 was the most common clones. OS-MRSA was reported for the first time.

CLC Number:

GENG Wen-jing, LI Wen-ting, SHI Wei, HEI Ming-yan. Molecular characteristics of antibiotic resistance and virulence in community acquired methicillin-resistant Staphylococcus aureus from neonates with skin and soft tissue infections[J]. Chinese Journal of Evidence -Based Pediatric, 2019, 14(6): 438-442.

[1]	ZHOU Jihua, CHEN Yang, CHEN Weiming, ZHOU Yuanfeng, SHEN Quanli, ZHANG Yi, LU Guoping. Clinical characteristic and prognosis of ischemic stroke in pediatric intensive care unit：A retrospective cohort study [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(6): 431-436.
[2]	HU Xiaojing，MA Xiaojing, ZENG Ziqian, ZHAO Zhengshan, WANG Dingmei，CHEN Hongyan, WANG Rui, ZHANG Chongfan, HUANG Guoying. Pulse oximetry or/and clinical assessment (cardiac murmur auscultation) in screening for critical congenital heart disease in the early neonatal stage: A systematic review and meta-analysis [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 325-333.
[3]	JIANG Li, JIN Ling, YANG Jing, DUAN Yanlong, ZHANG Ruidong, ZHANG Yuanyuan, YU Jiaole, WU Ying, LIN Wei, FAN Jia, HUANG Shuang, ZHANG Meng, ZHANG Yonghong, MA Xiaoli, ZHENG Huyong. Tumor lysis syndrome in 40 children with hematological malignancies: A case series report [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 370-373.
[4]	ZHONG Xuemei, MA Xin, ZHU Dan, GONG Youzhe, NING Huijuan, WANG Meijuan. Eosinophilic gastroenteritis in 6 children with moderate or severe anemia as initial presentation: A case series report [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 374-377.
[5]	GAN Mingyu, LI Gang, YU Hui, WU Bingbing, ZHOU Wenhao. The application value of Nanopore metagenomics sequencing in the rapid detection of pediatric respiratory tract pathogens [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 378-381.
[6]	. [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 388-390.
[7]	. [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 391-393.
[8]	. [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 394-396.
[9]	. [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 397-399.
[10]	. [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(5): 385-387.
[11]	. [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(4): 241-246.
[12]	Chinese Cooperative Group for the Management of Pediatric Enuresis Affiliated to Pediatric Nephrology Committee of Chinese Medical Doctor Association. Prevalence of nocturnal enuresis in children and adolescents aged 5 to 18 years in China [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(2): 81-86.
[13]	. Quick screening and management of children with suspected or confirmed COVID-19: A rapid advice guideline [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(1): 1-4.
[14]	. Expert advice on workflow management of neonatal respiratory virus infection [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(1): 5-9.
[15]	. Management advice on admission, hospitalization and infection prevention and control for pediatric patients during the epidemic of SARS-CoV-2 [J]. Chinese Journal of Evidence -Based Pediatric, 2020, 15(1): 10-14.

Molecular characteristics of antibiotic resistance and virulence in community acquired methicillin-resistant Staphylococcus aureus from neonates with skin and soft tissue infections

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments