Abstract: Objective To compare the pregnancy outcomes of pregnant women infected with SARS-CoV-1, MERS-CoV and SARS-CoV-2 and their impacts on newborns so as to provide evidence to guide the prevention and treatment of COVID-19. MethodsNeonates delivered by pregnant women diagnosed with coronavirus (SARS-CoV-1, MERS-CoV and SARS-CoV-2) infections through nucleic acid tests were included. Literature on pregnant women with SARS, MERS and COVID-19 and their neonates was searched in the database of PubMed, CBM and CNKI from January 1st, 2000 to March 9th, 2020 and a supplementary search was performed in the WHO COVID-19 literature database and references of the included literature. The literature was screened by reading the abstract and the full text according the eligibility criteria. Literature evaluation and data extraction were instructed and reviewed by professionals from Center for Clinical Guideline Development and Evaluation in Children's Hospital of Fudan University. ResultsA total of 42 pregnant women diagnosed with coronavirus infections and 36 live births were included for statistical analysis. There were 13 cases of SARS-CoV-1 infected pregnant women. Among them, 3 died (23%) and 4 of 10 surviving cases had a spontaneous abortion in the first trimester (40%), and the remaining 6 cases gave birth to 6 neonates (4 premature and 2 full-term) without SARS-CoV-1 infection. Two pregnant women were diagnosed with MERS-CoV infection. Both of them survived and 2 live-born neonates were born (1 premature and 1 full-term) without MERS-CoV infection. There were 27 confirmed cases of pregnant women with SARS-CoV-2 infection without deaths and 28 live births (1 twins) were delivered. Three of the newborns were tested positive for the nucleic acid test of SARS-CoV-2 through nasopharyngeal swabs with one severe case with congenital atrial septum defect and two mild cases. Close contact between mother and baby or family members after birth existed and no evidence of vertical placental transmission was found. There was no breastfeeding. All were cured and discharged. ConclusionThough the epidemiological and clinical characteristics of pregnant women infected by SARS-CoV-1 and MERS-CoV and their newborns were insufficiently reported in the literature, it was still of certain reference value for the prevention, diagnosis and treatment of SARS-CoV-2 infection in this population. Despite the high risk of bias in the literature, the outcomes of pregnant women with SARS-CoV-2 infection and their newborns at discharge were good.