Abstract: Objective:To investigate the growth status and influencing factors of growth retardation in children with juvenile idiopathic arthritis (JIA). Methods：The JIA patients with height-for-age Z-score (HAZ) <-2 SD during the follow up were enrolled as the case group, and patients with normal height (HAZ≥-2 SD) were enrolled as the control group. The factors affecting the growth of patients were investigated by a self-made questionnaire with 21 questions in 5 aspects including basic information, disease history, diet, lifestyle habits and family conditions. As rheumatologists performed diagnosis and follow-up treatment for children with JIA in the outpatient clinic, the child healthcare doctors carried out a face-to-face questionnaire survey and physical measurements during follow-up visits. Univariate and multivariate logistic regression models were used to analyze the risk factors of growth retardation in JIA patients after integrating the results of questionnaire in terms of age of onset, symptoms and physical signs, medications, diagnostic intervals, disease course, parents' education level and job. Results：From September 2018 to April 2019, 221 children with JIA who met the eligibility criteria were included in this analysis, including 103 males (46.6%) with the mean age of (7.8 ±3.7) years. JIA subtypes included oligoarthtiris (48.9%, n=108), systemic onset (26.2%, n=58), rheumatoid factor-negative polyarthritis (7.2%, n=16), rheumatoid factor-positive polyarthritis (16.3%, n=36), enthesitis-raleted arthritis (1.0%, n=2) and psoriatic arthritis (0.5%, n=1). Eighty-eight patients were treated by glucocorticoid (GCs), 72 were treated by biological preparations, and 61 were treated by other medicine. Thirty-three children (14.9%) were combined with growth retardation, and the HAZ among the subtype of oligoarthtiris, systemic-onset and polyarthritis was (-0.34 ±1.09) vs (-1.53 ±1.50) vs (-0.80 ±1.19), respectively. Univariate logistic regression showed clinical course, disease activity, glucocorticoid hormone therapy, pickiness, less outdoor activity time were factors influencing the linear growth of JIA. Multivariate logistic regression analysis showed that the GCs therapy(OR=7.227, 95%CI:1.877-27.817), the course more than 3 years(OR=4.278, 95%CI: 1.322-13.843) and outdoor activities less than 1 hour(OR=4.078, 95%CI: 1.252-13.288) were independent predictors of growth retardation in children with JIA (P＜0.05). Conclusion：Growth retardation was ubiquitous in JIA patients. The long disease course, GCs therapy and less outdoor activity time were main risk factors affecting the linear growth of JIA patients.