Abstract: ObjectiveTo analyze the clinical manifestations, endoscopic and histopathological characteristics of eosinophilic gastroenteritis（EGE）and to evaluate the efficacy and prognosis of diet and glucocorticoid therapy. MethodsA retrospective analysis was made for clinical data of patients with EGE who were hospitalized in the Department of Gastroenterology of Anhui Provincial Children's Hospital from February 2016 to February 2020, including gender, age at first diagnosis, course of disease, time of diagnosis, clinical manifestations, history of allergy, family history, EGE classification, laboratory examination, imaging examination, endoscopy, pathology, treatment and follow-up. ResultsA total of 22 patients were included into the analysis with 15 males and 7 females， with the median age of 7 years (3 months to 13 years). The most common gastrointestinal symptoms were abdominal pain (16 cases, 72.7%), diarrhea (13 cases, 59.1%) and abdominal distention (9 cases, 40.9%). In addition, the most common extraintestinal symptoms were anemia (10 cases, 45.5%) and weight loss (5 cases, 22.7%). The serum total IgE level, the ratio of eosinophil in peripheral blood and D-dimer were elevated for 18 cases (81.8%),15 cases (68.2%) and 7 cases (31.8%) ，respectively. In gastroscopy, 12 out of 22 cases (54.6%) were ulcers and 3 cases (13.6%) showed atrophy of duodenal villi. In colonoscopy, 4 out of 14 cases (28.6%) showed normal mucosa and 6 cases (42.9%) were affected on the terminal ileum. The positive rate was high(≥20 eos·HPF-1) in duodenum (52.6%) and terminal ileum (46.2%). Diet therapy and glucocorticoid therapy could alleviate symptoms. In particular, glucocorticoid therapy combined with diet could heavily reduce the infiltration of eosinophils in histology, which presented statistically significant differences compared with that of the single diet therapy（P＝0.002）. The recurrence rate reached 15.8%. ConclusionEGE gives no specific clinical symptoms. Possibility of EGE should be taken into consideration for patients with high level of serum total IgE and high ratio of eosinophil in peripheral blood. Multi-point endoscopic biopsy and histological examination are helpful for the diagnosis.