Abstract: Objective To investigate the association between TGF-β3 polymorphisms and the susceptibility to non-syndromic cleft 1∶P with or without cleft palate (NSCL/P) in Asian population using Meta-analysis.Methods Electionic detabeses including PubMed, Cochrane Library, Embase, Chinese Science and Technology Academic Journal, Chinese Journal Full-text Database, Chinese Biomedical Literature Database and Wanfang database were searched for relevant literature from inception of databases to Januatr 2019. Two researchers selected the literature and extracted the data independently according to the inclusion and exclusion criteria. A Meta-analysis was performed using STATA12.0 software and publication bias test were performed by funnel Plots.Results A total of nine case-control studies were included in the present Meta-analysis, including 806 cases and 781 healthy control. Meta-analysis showed that there was significant association between TGF-β3 polymorphism and susceptibility to NSCL/P under allele model (G vs A: OR=1.23, 95%CI: 1.04-1.47), additive model (GG vs AA: OR=1.72, 95%CI: 1.17-2.55), Co-dominant model (GG vs GA: OR=1.50, 95%CI: 1.15-1.98) and dominant model (GG vs GA+AA: OR=1.50, 95%CI: 1.16-1.94). However, there was no significant association between them under recessive model (AA vs GA+GG: OR=0.97, 95%CI: 0.72-1.30).Conclusion TGF-β3 polymorphism is associated with an increased risk of NSCL/P in Asian population.

Key words: Meta-analysis, NSCL/P, Polymorphism, Systematic review, TGF-β3