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Chinese Journal of Evidence -Based Pediatric ›› 2017, Vol. 12 ›› Issue (3): 180-184.

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The non-PCV13 serotypes were frequent among Streptococcus pneumoniae isolated from nasopharyngeal samples of hospitalized children with respiratory infection in a grade two hospital in western China

WEN De-nian1,4, LIU Ying2,4, SHI Wei2, ZENG Shao-qi1 , ZENG Hai-ling3, TANG Ping3, HUANG Xiao-gang1, YAO Kai-hu2   

  1. 1 Department of clinical laboratory,People's Hospital of Zhongjiang County, Deyang 618100,China; 2 Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045,China; 3 Department of Pediatrics ,People's Hospital of Zhongjiang County, Deyang 618100,China; 4 Co-first author
  • Received:2017-05-22 Revised:2017-06-25 Online:2017-06-25 Published:2017-06-25
  • Contact: YAO Kai-hu

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Abstract:

Objective: To investigate the carriage rate, serotype distribution and antibiotic resistance profiles of Streptococcus pneumoniae (S.pneumoniae) among hospitalized children with respiratory tract infections in grade two hospital in Zhongjiang County, Sichuan and to determine the epidemiological characters of these S.pneumoniae isolates. Methods: Nasopharyngeal swabs of hospitalized children with respiratory tract infections aged from 1 month to 14 years were collected from January to December 2015 at the Zhongjiang County Hospital, and S.pneumoniae was cultured. The serotypes were detected by capsule swelling experiment to assess the coverage rate of 13 valent pneumococcal conjugate vaccine (PCV13). The sensitivity against 16 antimicrobial agents were detected by E-test or disk diffusion method for approximately half of S.pneumoniae isolates randomly selected based on the serotypes. Results: The nasopharyngeal carriage rate of S.pneumoniae was 18.4% (199/1082). The common serotypes were 19F (14.6%), 19A (10.6%), 34 (10.1%), 6A (9.0%), 23F (7.5%), 6B (7.5%) and 23A(7.0%). The coverage rate of PCV13 was 54.8%. The proportion of non-PCV13 types was up to 45.2%. All of the isolates were sensitive to penicillin using the parenteral breakpoints, but the sensitive rate decreased to 9.1% for the oral penicillin breakpoints. The sensitivity rate of amoxycillin/clavulanate was 97%. All of the isolates were sensitive to ceftriaxone, vancomycin, levofloxacin and linezolid. However, all of the isolates were resistant to erythromycin and azithromycin.ConclusionColonization of S.pneumoniae was frequent in the nasopharynx of children with respiratory tract infections in Zhongjiang. About half of the S.pneumoniae isolates were identified as the PCV13 types. Non-PCV13 serotypes were common in the county, in which type 34 and 23A were frequent, which should be monitored for long time and in wider range. The isolates showed a high resistance to oral penicillin and erythromycin, but sensitive to parenteral penicillin, ceftriaxone and vancomycin.

Key words: Antibiotic resistance, Carriage rate, Children    , Serotype distribution, Streptococcus pneumoniae

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