Abstract: Objective To investigate and compare the research topics of interventional diagnosis and therapy of congenital heart disease (CHD) through visualized structure networks based on path finder network (PFNET) analysis at home and abroad, point out the advantage and weakness of the native studies in this field. Methods Medline database and China Biology Medicine disc (CBM) using MeSH keywords "heart defect, congenital" and "cardiac catheterization" were searched in March, 2011. After core key words had been charactered by Endnote X4 software, the co-occurrence matrix was built. After that, PFNET analysis was completed, leading the outside linking strength to be calculated. Then draw visualized network in Ucinet 6.0 software. Results The search results included 3 000 and 1 015 articles in each database, which were imported into Endnote X4 software.The visualized structure of research topics was successfully built, and the structural differences between native and overseas researches were directly reflected. Clinic demands were the original driving force in both native and oversea research developments. The overseas research topics were more sufficient and fully developed, while the native researches showed more independent with less connection with open surgical procedure. And the characteristics of native researches were formed during the past 30 years with high speed development. Conclusions Visualized structure networks based on PFNET analysis provide a systemic study about research topics of interventional diagnosis and therapy of CHD, intuitively illustrate the connections and developmental trends of the research topics in this field.