Abstract: AbstractObjective：To study the application of continuous blood purification(CBP) in Chinese pediatric critical care medicine from 2012 to 2016. Methods：A questionnaire named Application Status of Continuous Blood Purification Technology in 2012 was revised and perfected according to a crosssectional study. The Chinese Medical Association and Chinese Medical Doctor Association pediatric emergency or critical care unit members were selected as the investigation hospital. The survey contents: ① the nature, size and number of PICU beds of investigative hospitals; ②the implementation of peritoneal dialysis (IPD), hemodialysis (IHD), continuous renal replacement therapy (CRRT), plasma exchange (TPE), hemoperfusion (HP), blood adsorption (PA) and artificial liver support (ALSS); ③ the application in different diseases and the complications of CBP. Participated hospitals received a unified training and then finished filling out the questionnaire. Results：From December 30, 2016 to March 30, 2017, 53/55 hospitals in 39 cities of 28 provinces completed filing out the questionnaires, among which there were 39 pediatric hospital, 14 general hospitals and 49 Thirdlevel gradeA hospitals. All the 53 hospitals had PICU wards, and the average bed number of PICU was 25. 23 hospitals carried out CRRT, with 6 618 cases; 32 hospitals carried out TPE with 2 580 cases; 23 hospitals carried out HP with 2 238 cases; 20 hospitals carried out ALSS with 961 cases. The number of cases using various blood purification techniques showed an increasing trend year by year, while the proportion of IPD showed a downward trend.The implementation of CBP was mainly in ICU in more than 80% hospitals, followed by nephrology. CBP is mainly used in the treatment of sepsis (24.3%), MODS (20.3%), drug poisoning (12.7%) and other diseases.Neonatal CBP has been carried out in 9 hospitals, and 46 neonates received CBP treatment.1 093 children with liver failure were treated with CBP; the survival rates of each model were HP 85.7%, TPE+HP 72%, TPE 70.5%, CRRT 69.8%, TPE+CRRT 50%. The leading complication of CBP included deep vein catheter suction, membrane occlusion and so on.Conclusion：CBP is rapidly popularized in pediatric critical care in China from 2012 to 2016 and widely used in the treatment of sepsis.