Abstract: Background：The clinical manifestations of children with cerebral palsy are diverse, and there are few studies analyzing the characteristics of children with cerebral palsy of different genders with large sample data in China. Objective：To explore the gender differences in clinical data of children with cerebral palsy. Design：Case series report. Methods：General information, perinatal risk factors, and clinical features of children with cerebral palsy who were hospitalized in the Third Affiliated Hospital of Zhengzhou University from January 2019 to February 2022 were retrospectively collected. Main outcome measures：Gender differences in clinical features of children with cerebral palsy. Results：A total of 486 children with cerebral palsy were included, including 323 males and 163 females. The proportion of cesarean section, premature infants and macrosomia in males was significantly higher than that in females, while the proportion of normal birth weight children was significantly lower than that in females. In the comparison of birth seasons between groups, the proportion of males born in spring was significantly lower than that of females, while the proportion of winter births was significantly higher than that of females. The proportion of pregnancy complication, asphyxia, cerebral hemorrhage, hypoxic-ischemic encephalopathy and hypoglycemia in males was significantly higher than that in females. The proportion of grade IV and V in the Gross Motor Function Classification System was significantly higher than that in females, and the proportion of abnormal white matter in MRI classification was significantly higher than that in female children. Differences were statistically significant across all comparisons. Conclusion：There are gender differences in some clinical data of children with cerebral palsy. Most of the children with cerebral palsy are males and the severity is more serious than that of females.

Key words: Cerebral palsy, Gender, Risk factor, Children