Abstract:

Objective To explore the influence of infection on Kawasaki disease (KD) and coronary artery lesions. Methods We retrospectively reviewed the clinical records of patients with KD treated at Beijing Children's Hospital, Capital Medical University from January 2005 to December 2014, the intercepted demographic information, clinical findings, echocardiography findings of acute and sequelae phase and outcomes. The typical KD, incomplete KD, IVIG resistance, the degree of coronary artery lesions and co-infection were re-screened for each case. The differences of clinical manifestations were analyzed between the infected group and non-infected group. The differences of infections were analyzed between the coronary artery lesions group and non-coronary lesions group. Results The proportion of KD combined with infection and KD combined with coronary artery lesions was 57.1% (1331/2 331) and 36.0%(840/2 331), respectively. There were significant differences in age, length of fever (days) and incomplete KD. There were significant differences in mycoplasma pneumoniae infection and gastrointestinal infections associated with diarrhea between the coronary artery lesions group and non-coronary lesions group (P values were 0.004 and 0.047, respectively). Conclusion This study showed that KD children with infection were common in patients below 1 year old and characterized by incomplete KD. KD children with mycoplasma pneumoniae infection and gastrointestinal infection associated with diarrhea were prone to develop coronary artery lesions.