中国循证儿科杂志 ›› 2015, Vol. 10 ›› Issue (6): 463-469.

• 综述 • 上一篇    下一篇

孤独症谱系障碍动物模型的研究进展

胡纯纯,徐秀   

  1. 复旦大学附属儿科医院 上海,201102
  • 收稿日期:2015-06-10 修回日期:2015-12-24 出版日期:2015-12-05 发布日期:2015-12-04
  • 通讯作者: 徐秀

Current progress in animal models of autism spectrum disorders

HU Chun-chun, XU Xiu   

  1. Children's Hospital of Fudan University, Shanghai 201102, China
  • Received:2015-06-10 Revised:2015-12-24 Online:2015-12-05 Published:2015-12-04
  • Contact: XU Xiu

摘要:

孤独症谱系障碍是一种神经发育障碍性疾病。其病因多样,多数认为是环境与遗传的共同结果。动物模型,作为孤独症谱系障碍疾病的研究工具,通过生化作用诱导与基因分子缺陷,从而获得不同的孤独症动物亚型,以研究孤独症的病因,行为学表型,探索药物及干预疗法的安全性和有效性,以期提高孤独症个体的生活质量。

Abstract:

ASD is a neurodevelopmental disorder, with different etiologies. .Generally, it’s a combination of environmental factors and genes. As a research tool, animal models play an important role in ASD research by using biological and genetic molecular defects inducement, to gain more understanding of the mechanism, behavioral phenotype, medication and intervention of the disease, thus raising hope to improve the quality life of autism individuals.