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中国循证儿科杂志

中国循证儿科杂志 ›› 2020, Vol. 15 ›› Issue (3): 206-209.

• 论著 • 上一篇    下一篇

上海市境外输入性儿童新型冠状病毒感染38例病例系列报告

蔡洁皓1,5，夏爱梅1,5，王相诗1,5，曾玫1，王佳丽1，田鹤1，常海岭1，张进强2，魏仲秋1，李晶晶1，陆效笑3，王建设1，朱启鎔1，葛艳玲1，赵隽4   

  1. 1 复旦大学附属儿科医院感染传染科 上海，201102； 2 复旦大学附属儿科医院厦门分院感染传染科 厦门，361006； 3 复旦大学附属妇产科医院 上海，200011；4 上海市公共卫生临床中心儿科 上海，201508； 5 共同第一作者
  • 收稿日期:2020-05-18 修回日期:2020-06-03 出版日期:2020-06-25 发布日期:2020-06-25
  • 通讯作者: 葛艳玲，赵隽

38 imported pediatric cases of SARS-CoV-2 infection from abroad in Shanghai: A case series report

CAI Jie-hao1,5, XIA Ai-mei1,5, WANG Xiang-shi1,5,  ZENG Mei1, WANG Jia-li1, TIAN He1, CHANG Hai-ling1, ZHANG Jin-qiang2, WEI Zhong-qiu1, LI Jing-jing1, LU Xiao-xiao3, WANG Jian-she1, ZHU Qi-rong1, GE Yan-ling1, ZHAO Jun4   

  1. 1 Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai 201102, China; 2 Department of Infectious Diseases, Children's Hospital of Fudan University Xiamen Branch, Xiamen 361006, China; 3 Obstetrics and Gynecology Hospital of Fudan University, Shanghai 201102, China; 4 Department of Pediatrics, Shanghai Public Health Clinical Center, Shanghai 201508, China; 5 Co-first author
  • Received:2020-05-18 Revised:2020-06-03 Online:2020-06-25 Published:2020-06-25
  • Contact: GE Yan-ling, ZHAO Jun

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摘要： 目的：了解上海市收治的境外输入性儿童新型冠状病毒（SARS-CoV-2）感染病例的流行病学和临床特征。方法：收集2020年3月14日至2020年4月8日在上海市入境的38例经呼吸道标本核酸检测阳性确诊的SARS-CoV-2感染的儿童病例资料，分析其流行病学史、临床表现、实验室检查、胸部影像学以及治疗和转归情况。结果：38例患儿中，无症状感染16例（42.1%），非重症肺炎14例（36.8%），轻型8例（21.1%）；37例（97.4%）来自欧洲和北美；26例（68.4%）无明确感染病例接触史或者聚集发病，12例（31.6%）有家庭内或学生宿舍内感染病例接触史。非肺炎组和肺炎组病例性别和年龄差异无统计学意义 （P>0.05）。14例肺炎病例随访影像学均显示肺部病灶吸收治愈。16例无症状感染者在住院期间未出现症状和肺部影像学异常。7例有发热，热程平均2.5 d，11例有咳嗽，5例有咽痛，4例有鼻塞和流涕症状，6例使用过1~6 d羟氯喹治疗。38例均治愈出院，住院时间平均（18.5±3.4）d。结论：境外输入性儿童SARS-CoV-2感染病例以无症状感染常见。有肺炎和无肺炎实验室检查结果无明显特异性。无症状感染者和非重症病例不推荐常规胸部影像学复查。

Abstract: Objective:To understand the epidemiological and clinical features of the 38 imported pediatric cases of SARS-CoV-2 infection in Shanghai. Methods:The clinical data were collected from the 38 imported pediatric cases with laboratory-confirmed SARS-CoV-2 infection from March 14 to April 8 2020. The epidemiological history, clinical presentations, laboratory findings, chest radiological findings, treatment and outcomes were analyzed. Results:Of the 38 imported cases, 16 (42.1%) were asymptomatic, 14 (36.8%) had non-severe pneumonia, and 8 (21.1%) had mild illness. There were 37 cases (97.4%) from Europe and North America, 26 cases (68.4%) without a definitive contact history, and 12 cases (31.6%) linked with family cluster infection or exposure to suspected cases in school dormitory. There was no statistical difference between the pneumonia group and the non-pneumonia group in terms of gender and age（P>0.05）. The 14 pneumonia cases showed absorption of lung lesions by follow-up chest radiology, and the 16 asymptomatic cases did not develop any symptoms and radiological abnormalities during hospitalization. Seven cases had fever with a mean duration of 2.5 days, 11 had mild cough, 5 had sore throat, and 4 had runny nose. Hydroxychloroquine was used in the 6 cases for 1-6 days. All cases recovered uneventfully with a mean length of hospitalization of 18.5±3.4 days. Conclusion:Asymptomatic infection was common among the imported pediatric cases of COVID-19 from abroad. There was no obvious difference of the laboratory findings between the pneumonia group and the non-pneumonia group. Routine re-detection of radiography is not recommended for asymptomatic and mild cases.