欢迎访问《中国循证儿科杂志》官方网站，今天是
English Version
中国循证儿科杂志

中国循证儿科杂志 ›› 2016, Vol. 11 ›› Issue (3): 195-199.

• 论著 • 上一篇    下一篇

实验室指标与川崎病并发冠状动脉损伤关联性的系统评价和Meta分析

周雪晴，罗亚玲，周天津，黄仕鑫   

  1. 重庆医科大学医学信息学院 重庆，400016
  • 收稿日期:2016-03-16 修回日期:2016-06-25 出版日期:2016-06-25 发布日期:2016-06-25
  • 通讯作者: 罗亚玲

Six biomarkers associated with coronary artery lesions secondary to Kawasaki disease: a systematic review and meta-analysis

ZHOU Xue-qing, LUO Ya-ling, ZHOU Tian-jin, HUANG Shi-xin   

  1. College of Medical Informatics, Chongqing Medical University, Chongqing 400016, China
  • Received:2016-03-16 Revised:2016-06-25 Online:2016-06-25 Published:2016-06-25
  • Contact: LUO Ya-ling

PDF

1665

摘要：

目的 定量评估6项实验室指标与川崎病（KD）急性期并发冠状动脉损伤（CAL）的关联性，以期为早期判别KD并发CAL提供依据。方法 检索Web of Science、PubMed、Cochrane图书馆、EBSCO、中国知网、万方数据库和维普数据库，纳入6项实验室指标（WBC、Hb、PLT、CRP、ESR和ALB）与KD并发CAL相关性的病例对照研究文献，检索时间限定为2000年1月1日至2016年4月30日。以EndNote X7软件管理文献，依据纳入和排除标准筛选文献，以NOS量表评估纳入文献偏倚风险。提取各实验室指标与CAL关联的经多因素分析调整的OR及其95%CI，采用Stata 12.0软件行Meta分析，根据异质性结果选择相应的效应模型。结果 12篇病例对照研究文献进入Meta分析，纳入4 900例KD患儿，发生CAL 1 256例。NOS量表评估结果，8篇文献评为7分，4篇文献评为6分。WBC、Hb、PLT、CRP、ESR和ALB与CAL相关性的Meta分析分别纳入2、3、8、3、4和5篇文献。WBC、Hb、CRP和ESR与CAL的发生无显著关联， OR（95%CI）分别为0.32（0.02~4.91）、0.94（0.88~1.01）、1.11（0.97～1.26）和1.09（0.98~1.20）。PLT和ALB与CAL的发生相关，随机效应模型汇总的OR（95%CI）分别为1.020（1.001~1.039）和0.87（0.80~0.95）。结论 KD急性期ALB降低和PLT升高为发生CAL的危险因素。

Abstract:

Objective To explore the relationship between 6 common biomarkers and kawasaki disease (KD) with coronary artery lesions(CAL) in the acute phase.Methods Case-control studies from the database of Web of Science, PubMed, The Cochrane Library, EBSCO, China National Knowledge Infrastructure, Wanfang Chinese Periodical Database and VIP Information were recruited to summarize the association between 6 biomarkers (WBC, Hb, PLT, CRP, ESR, ALB) with CAL from January 1 2000 to April 30 2016, and the biomarkers were adjusted by multivariate regression analysis. According to the inclusion and exclusion criteria the studies were selected through EndNote X7 software. The quality of the studies was evaluated by Newcastle-Ottawa Scale(NOS).Stata 12.0 software was applied for the meta-analysis, OR and 95%CI were extracted from each study. The effect model was selected according to the heterogeneity results.Results Twelve clinical studies with a total of 4 900 patients,1 256 patients with CAL were identified.6 factors were included . Six studies were 7 points and 4 studies were 6 points. There was no statistical significance between WBC, Hb, CRP, ESR with CAL, the results of OR and 95%CI were as follows: 0.32 (0.02-4.91), 0.94 (0.88-1.01), 1.11（0.97-1.26）and 1.09(0.98-1.20). PLT and ALB were related to the CAL, the results were as follows: 1.020(1.001-1.039) and 0.87(0.80-0.95). PLT and ALB were used as random model.Conclusion The major risk factors for KD with CAL in the acute stage were increased PLT and decreased ALB.