系统性红斑狼疮产妇孕期体重增长对新生儿出生体重影响的巢式病例对照研究

doi:10.3969/j.issn.1673-5501.2019.02.002

摘要/Abstract

摘要： 目的考察系统性红斑狼疮(SLE)产妇孕期体重增长(GWG)对新生儿出生体重的影响。方法以上海交通大学医学院附属仁济医院(我院)产科分娩的SLE产妇及其新生儿为研究对象。采集产妇一般情况(年龄、身高、孕前体重、教育程度、GWG、既往疾病史、分娩孕周)、第一次产检指标(收缩压、舒张压、胆固醇、甘油三酯、空腹血糖)、新生儿性别、Apgar评分及出生体重。根据年龄和教育程度1:3匹配健康产妇及其新生儿作为对照。产妇GWG与新生儿出生体重关系采用一般线性回归分析。结果共纳入SLE产妇45例和健康产妇135例。所有产妇平均年龄(29.0±3.0)岁,新生儿平均出生体重(3 198.8±501.8)g。SLE组GWG显著低于对照组,(12.4±5.5)kg vs (15.0±5.1)kg, P=0.004,GWG 低于适宜体重增长的比例显著高于对照组(37.8% vs 16.3%, P<0.01)。将所有产妇按GWG进行四分位分组,结果显示随着GWG增长,新生儿出生体重明显增加。与GWG处于最低四分位的SLE产妇相比,处于最高四分位的产妇的新生儿出生体重多(246.4±234.1)g,差异无统计学意义。结论 SLE产妇GWG明显低于正常产妇,随着GWG的增加,新生儿出生体重有增加趋势。

关键词: 出生体重, 系统性红斑狼疮, 孕期体重增长

Abstract: Objective To investigate the effects of gestational weight gain (GWG) in women with systemic lupus erythematosus (SLE) on birth weight of their neonates.Methods SLE women and their neonates were recruited from Renji Hospital. Maternal demographic parameters (age, height, pre-pregnancy body weight, education level, GWG, past disease history, gestational age), clinical parameters at the first check-up (systolic and diastolic blood pressure, total cholesterol and triglycerides, fasting blood glucose), and neonatal sex, Apgar Score and birth weight were collected from medical records. Healthy pregnant women and their neonates were matched (1:3) based on age and education level as control. The relationship between GWG and neonatal birth weight was analyzed by the general linear regression.Results A total of 180 women (45 pregnant women with SLE and 135 healthy pregnant women) were included in the current study. The average age and birth weight were 29.0±3.0 years and 3 198.8±501.8 g, respectively. GWG was lower in SLE group than that in control group (12.4±5.5 kg vs 15.0±5.1 kg, P=0.004). The proportion of inadequate GWG in the SLE group was higher than that in the control group (37.8% vs 16.3%, P<0.01). A high GWG was associated with a larger birth weight in all participants. Compared with neonates whose mothers were in the lowest quartile group, neonates whose mothers were in the highest quartile were likely to get an extra birth weight (246.4±234.1g), however, it did not reach a significant difference.Conclusion GWG in SLE women was lower than that of healthy women, which might result in a low birth weight.

Key words: Birth weight, Gestational weight gain, Systemic lupus erythematosus

唐墨莲, 赵卫秀, 沈敏, 李浩捷, 谈韬, 徐仁应, 万燕萍. 系统性红斑狼疮产妇孕期体重增长对新生儿出生体重影响的巢式病例对照研究[J]. 中国循证儿科杂志, 2019, 14(2): 87-90.

TANG Mo-lian, ZHAO Wei-xiu, SHEN Min, LI Hao-jie, TAN Tao, XU Ren-ying, WAN Yan-ping. Nested case-control study on gestational weight gain in women with systemic lupus erythematosus and its effect on birth weight of their neonates[J]. Chinese Journal of Evidence -Based Pediatric, 2019, 14(2): 87-90.

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